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KMID : 1123920040180010243
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 1 p.243 ~ p.249
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Kami-bang-pung-tong-sung-san is Involved in Regulating Physiological Parameters Associated with Hypertension in Spontaneously Hypertensive Rat
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Na Young-Cheul
Kim Dong-Hee
Namgung Uk
Lee Yang-Koo
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Abstract
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KBPT is the fortified prescription of Bang-pung-tong-sung-san(BPTS) by adding Spatholobi Clulis and Salviae Miltiorrzae Radix. BPTS prescription has been utilized in oriental medicine for the treatments of vascular diseases including hypertension, stroke, and arteriosclerosis. Yet, the overall mechanism underlying its activity at the cellular levels remains unknown. Using spontaneously hypertensive rat (SHR) model, we investigated whether the KBPTS has an effect on the pathophysiological parameters related to hypertension. Pretreatment of SHR with KBPTS was found to lower blood pressure and heartbeat rate. Levels of aldosterone. dopamine, and epinephrine were found to be significantly reduced in the serum of KBPTS-treated SHR. Histological examination of adrenal cortex and superior aorta showed that tissues from KBPTS-treated SHR rats were more intact and cleaner compared to saline-treated control. Levels of superoxide dismutase (SOD) protein in adrenal gland, aorta, myocardial tissue, and kidneys were higher in KBPTS-treated animals than control group. The present data suggest that KBPTS may play a role in normalizing cardiovascular function in SHR by controlling hypertension-related blood factors and superoxide stressors.
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KEYWORD
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Kami-bang-pung-tong-sung-san, spontaneously hypertensive rat (SHR), hypertension, blood, catecholamine, superoxide dismutase (SOD)
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